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Target
WD repeat-containing protein 5
Ligand
BDBM50164795
Substrate
n/a
Meas. Tech.
ChEMBL_1575810 (CHEMBL3801642)
Kd
30±n/a nM
Citation
 Getlik, M; Smil, D; Zepeda-Velázquez, C; Bolshan, Y; Poda, G; Wu, H; Dong, A; Kuznetsova, E; Marcellus, R; Senisterra, G; Dombrovski, L; Hajian, T; Kiyota, T; Schapira, M; Arrowsmith, CH; Brown, PJ; Vedadi, M; Al-Awar, R Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). J Med Chem 59:2478-96 (2016) [PubMed]  Article 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Human
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM50164795
Synonyms:
CHEMBL3799608
Type:
Small organic molecule
Emp. Form.:
C25H25F3N6O3
Mol. Mass.:
514.4996
SMILES:
CN1CCN(CC1)c1ccc(cc1NC(=O)c1c[nH]c(=O)cc1C(F)(F)F)-c1ccc(NC(C)=O)nc1
Structure:
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