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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50172624
Substrate
n/a
Meas. Tech.
ChEMBL_1581225 (CHEMBL3811011)
EC50
7±n/a nM
Citation
 Stachel, SJ; Zerbinatti, C; Rudd, MT; Cosden, M; Suon, S; Nanda, KK; Wessner, K; DiMuzio, J; Maxwell, J; Wu, Z; Uslaner, JM; Michener, MS; Szczerba, P; Brnardic, E; Rada, V; Kim, Y; Meissner, R; Wuelfing, P; Yuan, Y; Ballard, J; Holahan, M; Klein, DJ; Lu, J; Fradera, X; Parthasarathy, G; Uebele, VN; Chen, Z; Li, Y; Li, J; Cooke, AJ; Bennett, DJ; Bilodeau, MT; Renger, J Identification and in Vivo Evaluation of Liver X Receptorß-Selective Agonists for the Potential Treatment of Alzheimer's Disease. J Med Chem 59:3489-98 (2016) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Human
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50172624
Synonyms:
CHEMBL3809494
Type:
Small organic molecule
Emp. Form.:
C28H25ClF3N5O3
Mol. Mass.:
571.978
SMILES:
CN(C)C(=O)c1ccc(cc1Cl)-c1cnc(N2CCN(CC2)C(=O)[C@](O)(c2ccccc2)C(F)(F)F)c(c1)C#N |r|
Structure:
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