Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM10857
Substrate
n/a
Meas. Tech.
ChEMBL_1584563 (CHEMBL3820554)
Kd
5880±n/a nM
Citation
Gaspari, R; Rechlin, C; Heine, A; Bottegoni, G; Rocchia, W; Schwarz, D; Bomke, J; Gerber, HD; Klebe, G; Cavalli, A Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies. J Med Chem 59:4245-56 (2016) [PubMed] Article
More Info.:
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA2 | CAH2_BOVIN | Carbonic anhydrase | Carbonic anhydrase 2 | Carbonic anhydrase II | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29115.93
Organism:
Bos taurus
Description:
n/a
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK
Inhibitor
Name:
BDBM10857
Synonyms:
4-aminobenzene-1-sulfonamide | CHEMBL21 | Sulfanilamide | aromatic sulfonamide compound 5 | aromatic/heteroaromatic sulfonamide 2 | halogenosulfanilamide deriv. 5a
Type:
Small organic molecule
Emp. Form.:
C6H8N2O2S
Mol. Mass.:
172.205
SMILES:
Nc1ccc(cc1)S(N)(=O)=O