Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM14774
Substrate
n/a
Meas. Tech.
ChEMBL_1621695 (CHEMBL3863978)
IC50
>1000±n/a nM
Citation
 Grŕcia, J; Buil, MA; Castro, J; Eichhorn, P; Ferrer, M; Gavaldŕ, A; Hernández, B; Segarra, V; Lehner, MD; Moreno, I; Pagčs, L; Roberts, RS; Serrat, J; Sevilla, S; Taltavull, J; Andrés, M; Cabedo, J; Vilella, D; Calama, E; Carcasona, C; Miralpeix, M Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships. J Med Chem 59:10479-10497 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Human
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM14774
Synonyms:
3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | CHEMBL193240 | DAXAS | ROF | Roflumilast
Type:
Small organic molecule
Emp. Form.:
C17H14Cl2F2N2O3
Mol. Mass.:
403.207
SMILES:
FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl
Structure:
Search PDB for entries with ligand similarity: