Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50114418
Substrate
n/a
Meas. Tech.
ChEMBL_157365 (CHEMBL762041)
IC50
7.0±n/a nM
Citation
Billah, M; Cooper, N; Cuss, F; Davenport, RJ; Dyke, HJ; Egan, R; Ganguly, A; Gowers, L; Hannah, DR; Haughan, AF; Kendall, HJ; Lowe, C; Minnicozzi, M; Montana, JG; Naylor, R; Oxford, J; Peake, JC; Piwinski, JJ; Runcie, KA; Sabin, V; Sharpe, A; Shih, NY; Warneck, JB Synthesis and profile of SCH351591, a novel PDE4 inhibitor. Bioorg Med Chem Lett 12:1621-3 (2002) [PubMed] Article
More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rat
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
Inhibitor
Name:
BDBM50114418
Synonyms:
8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic acid (3,5-dichloro-pyridin-4-yl)-amide | CHEMBL40200 | N-(3,5-dichloropyridin-4-yl)-8-methoxy-2-(trifluoromethyl)quinoline-5-carboxamide | SCH-365351
Type:
Small organic molecule
Emp. Form.:
C17H10Cl2F3N3O2
Mol. Mass.:
416.181
SMILES:
COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C(F)(F)F