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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50219015
Substrate
n/a
Meas. Tech.
ChEMBL_157225 (CHEMBL769549)
IC50
621±n/a nM
Citation
 Buckley, GM; Cooper, N; Davenport, RJ; Dyke, HJ; Galleway, FP; Gowers, L; Haughan, AF; Kendall, HJ; Lowe, C; Montana, JG; Oxford, J; Peake, JC; Picken, CL; Richard, MD; Sabin, V; Sharpe, A; Warneck, JB 7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma. Bioorg Med Chem Lett 12:509-12 (2002) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50219015
Synonyms:
CHEMBL146865
Type:
Small organic molecule
Emp. Form.:
C19H12Cl2N4O4
Mol. Mass.:
431.229
SMILES:
COc1ncc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2cc(oc12)-c1cccnc1
Structure:
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