Reaction Details Report a problem with these data
Target
Proteasome subunit beta type-5
Ligand
BDBM50234633
Substrate
n/a
Meas. Tech.
ChEMBL_1653530 (CHEMBL4002896)
IC50
>50000±n/a nM
Citation
 Qin, JM; Huang, RZ; Yao, GY; Liao, ZX; Pan, YM; Wang, HS Terminal functionalized thiourea-containing dipeptides as multidrug-resistance reversers that target 20S proteasome and cell proliferation. Eur J Med Chem 126:259-269 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50234633
Synonyms:
CHEMBL4064812
Type:
Small organic molecule
Emp. Form.:
C29H32BrClN4O2S
Mol. Mass.:
616.012
SMILES:
CC[C@H](C)[C@H](NC(=S)Nc1ccc(Br)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)Nc1ccc(C)c(Cl)c1 |r|
Structure:
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