Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM50018708
Substrate
n/a
Ki
0.5±n/a nM
Comments
PDSP_758
Citation
Toll, L; Berzetei-Gurske, IP; Polgar, WE; Brandt, SR; Adapa, ID; Rodriguez, L; Schwartz, RW; Haggart, D; O'Brien, A; White, A; Kennedy, JM; Craymer, K; Farrington, L; Auh, JS Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications. NIDA Res Monogr 178:440-66 (1998) [PubMed]
More Info.:
Target
Name:
Delta-type opioid receptor
Synonyms:
Delta opioid receptor | Delta-type opioid receptor | OPIATE Delta | OPRD1 | OPRD_PIG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25736.90
Organism:
GUINEA PIG
Description:
OPIATE Delta OPRD1 GUINEA PIG::P79291
Residue:
228
Sequence:
GIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILVITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
Inhibitor
Name:
BDBM50018708
Synonyms:
2-{2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-hydroxy-propionylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-3-hydroxy-butyric acid | CHEMBL124283 | DSLET | DSLET-OH | Tyr-D-Ser-Gly-Phe-Leu-Thr
Type:
Small organic molecule
Emp. Form.:
C33H46N6O10
Mol. Mass.:
686.7525
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O