Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM85667
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
3.08e+5± 6.0e+4 nM
Citation
Alagille, D; Pfeiffer, B; Scalbert, E; Ferry, G; Boutin, JA; Renard, P; Viaud-Massuard, MC Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors. J Enzyme Inhib Med Chem 19:137-43 (2004) [PubMed] Article
More Info.:
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN