Reaction Details
Report a problem with these data
![](/images/Email.png)
Target
Transthyretin
Ligand
BDBM249533
Substrate
n/a
Meas. Tech.
Scintillation Proximity RBP4 Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
10.9±n/a nM
Comments
extracted
Citation
![](/images/small/blackdot.gif)
More Info.:
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
Inhibitor
Name:
BDBM249533
Synonyms:
US10072016, Compound 131 | US10407433, Compound 131 | US10913746, Compound 131 | US11649240, Compound 131 | US9434727, 131 | US9777010, Compound 131
Type:
Small organic molecule
Emp. Form.:
C21H21F5N4O2
Mol. Mass.:
456.4091
SMILES:
CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cc(F)cc(F)c1C(F)(F)F