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Target
Histamine H2 receptor
Ligand
BDBM86188
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_3074
Citation
 McLeod, RL; Rizzo, CA; West, RE; Aslanian, R; McCormick, K; Bryant, M; Hsieh, Y; Korfmacher, W; Mingo, GG; Varty, L; Williams, SM; Shih, NY; Egan, RW; Hey, JA Pharmacological characterization of the novel histamine H3-receptor antagonist N-(3,5-dichlorophenyl)-N'-[[4-(1H-imidazol-4-ylmethyl)phenyl]-methyl]-urea (SCH 79687). J Pharmacol Exp Ther 305:1037-44 (2003) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40567.22
Organism:
Cavia porcellus (domestic guinea pig)
Description:
For the H2 receptor-binding assays, guinea pig striatum was used.
Residue:
359
Sequence:
MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
  
Inhibitor
Name:
BDBM86188
Synonyms:
CHEMBL366977 | SCH 79687
Type:
Small organic molecule
Emp. Form.:
C18H16Cl2N4O
Mol. Mass.:
375.252
SMILES:
Clc1cc(Cl)cc(NC(=O)NCc2ccc(Cc3cnc[nH]3)cc2)c1
Structure:
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