Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM57650
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay for biased ligands (antagonists) of the melanocortin 4 receptor (MC4R)
IC50
8430±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay for biased ligands (antagonists) of the melanocortin 4 receptor (MC4R) PubChem Bioassay (2012)[AID] 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM57650
Synonyms:
5-[2,5-bis(oxidanylidene)pyrrol-1-yl]-N-(3-chloranyl-4-methyl-phenyl)-2-morpholin-4-yl-benzamide | MLS000678894 | N-(3-chloro-4-methyl-phenyl)-5-maleimido-2-morpholino-benzamide | N-(3-chloro-4-methylphenyl)-5-(2,5-dioxo-1-pyrrolyl)-2-(4-morpholinyl)benzamide | N-(3-chloro-4-methylphenyl)-5-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-2-(4-morpholinyl)benzamide | N-(3-chloro-4-methylphenyl)-5-(2,5-dioxopyrrol-1-yl)-2-morpholin-4-ylbenzamide | SMR000269962 | cid_1335691
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O4
Mol. Mass.:
425.865
SMILES:
Cc1ccc(NC(=O)c2cc(ccc2N2CCOCC2)N2C(=O)C=CC2=O)cc1Cl |c:25|
Structure:
Search PDB for entries with ligand similarity: