Reaction Details Report a problem with these data
Target
COUP transcription factor 2
Ligand
BDBM97183
Substrate
n/a
IC50
6276±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2) PubChem Bioassay (2013)[AID] 
Target
Name:
COUP transcription factor 2
Synonyms:
ARP1 | COT2_HUMAN | COUP transcription factor 2 isoform a | NR2F2 | TFCOUP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45583.83
Organism:
Homo sapiens (Human)
Description:
gi_14149746
Residue:
414
Sequence:
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
  
Inhibitor
Name:
BDBM97183
Synonyms:
MLS003120814 | SMR001273177 | [(2S,6R)-6-[6-(cyclopentylamino)-9-purinyl]-4-[(4-phenylphenyl)methyl]-2-morpholinyl]methanol | [(2S,6R)-6-[6-(cyclopentylamino)purin-9-yl]-4-(4-phenylbenzyl)morpholin-2-yl]methanol | [(2S,6R)-6-[6-(cyclopentylamino)purin-9-yl]-4-[(4-phenylphenyl)methyl]morpholin-2-yl]methanol | cid_49778246
Type:
Small organic molecule
Emp. Form.:
C28H32N6O2
Mol. Mass.:
484.5927
SMILES:
OC[C@@H]1CN(Cc2ccc(cc2)-c2ccccc2)C[C@@H](O1)n1cnc2c(NC3CCCC3)ncnc12
Structure:
Search PDB for entries with ligand similarity: