Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM83925
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR).
EC50
67547±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of the daf-12 abnormal Dauer Formation: Luminescence-based cell-based dose response assay to identify agonists of the Liver-X-Receptor (LXR). PubChem Bioassay (2013)[AID] 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Human
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM83925
Synonyms:
MLS001005319 | SMR000348684 | [5-(2-nitrophenyl)-2-furanyl]-(1-pyrrolidinyl)methanethione | [5-(2-nitrophenyl)-2-furyl]-pyrrolidino-methanethione | [5-(2-nitrophenyl)furan-2-yl]-pyrrolidin-1-yl-methanethione | [5-(2-nitrophenyl)furan-2-yl]-pyrrolidin-1-ylmethanethione | cid_1540853
Type:
Small organic molecule
Emp. Form.:
C15H14N2O3S
Mol. Mass.:
302.348
SMILES:
[O-][N+](=O)c1ccccc1-c1ccc(o1)C(=S)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: