Reaction Details Report a problem with these data
Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM119360
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.5±n/a
Temperature
301.15±n/a K
IC50
<5±n/a nM
Comments
extracted
Citation
 Luk, K; Soth, M Imidazo pyrazines US Patent  US8673905 Publication Date 3/18/2014 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM119360
Synonyms:
US8673905, 76
Type:
Small organic molecule
Emp. Form.:
C25H31N9
Mol. Mass.:
457.5739
SMILES:
NCCC(Nc1nccc(n1)-c1cnc2c(N[C@H]3CC[C@H](N)CC3)nccn12)c1ccccc1 |r,wU:20.21,wD:17.17,(6.37,-4.38,;6.37,-2.84,;5.04,-2.07,;5.04,-.53,;3.7,.24,;2.37,-.53,;2.37,-2.07,;1.04,-2.84,;-.3,-2.07,;-.3,-.53,;1.04,.24,;-1.63,.24,;-2.88,-.66,;-4.12,.24,;-3.65,1.71,;-4.42,3.04,;-5.96,3.04,;-6.73,1.71,;-8.27,1.71,;-9.04,.38,;-8.27,-.96,;-9.04,-2.29,;-6.73,-.96,;-5.96,.38,;-3.65,4.38,;-2.11,4.38,;-1.34,3.04,;-2.11,1.71,;6.37,.24,;7.7,-.53,;9.04,.24,;9.04,1.78,;7.7,2.55,;6.37,1.78,)|
Structure:
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