Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM61947
Substrate
n/a
Meas. Tech.
EMSA
pH
7.5±n/a
Temperature
296.15±n/a K
IC50
7e+2± 3e+2 nM
Comments
extracted
Citation
 Mukherjee, S; Weiner, WS; Schroeder, CE; Simpson, DS; Hanson, AM; Sweeney, NL; Marvin, RK; Ndjomou, J; Kolli, R; Isailovic, D; Schoenen, FJ; Frick, DN Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication ACS Chem Biol 9:2393-2403 (2014) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
NS3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
67067.41
Organism:
Hepacivirus C
Description:
gi_125541954
Residue:
631
Sequence:
APITAYAQQTRGLLGCIITGLTGRDKNQVEGEVQIVSTAAQTFLATCINGVCWTVYHGAGTRTIASSKGPVIQMYTNVDQDLVGWPAPQGARSLTPCTCGSSDLYLVTRHADVIPVRRRGDGRGSLLSPRPISYLKGSSGGPLLCPAGHAVGIFRAAVCTRGVAKAVDFIPVEGLETTMRSPVFSDNSSPPAVPQSYQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGIDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGSAYDIIICDECHSTDATSILGIGTVLDQAETAGARLTVLATATPPGSVTVPHPNIEEVALSTTGEIPFYGKAIPLEAIKGGRHLIFCHSKKKCDELAAKLVALGVNAVAYYRGLDVSVIPASGDVVVVATDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEITLTHPITKYIMTCMSADLEVVT
  
Inhibitor
Name:
BDBM61947
Synonyms:
6-bromanyl-2-phenyl-1,2-benzothiazol-3-one | 6-bromo-2-phenyl-1,2-benzothiazol-3-one | 6-bromo-2-phenyl-1,2-benzothiazol-3-one (3) | KSC-09-117 | KUC105340N | cid_22416220
Type:
Small organic molecule
Emp. Form.:
C13H8BrNOS
Mol. Mass.:
306.178
SMILES:
Brc1ccc2c(c1)sn(-c1ccccc1)c2=O
Structure:
Search PDB for entries with ligand similarity: