Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM283824
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
pH
7.2±n/a
Temperature
298.15±n/a K
IC50
3.40±n/a nM
Comments
extracted
Citation
Bhide, RS; Duncia, JV; Hynes, J; Nair, SK; Pitts, WJ; Kumar, SR; Gardner, DS; Murugesan, N; Paidi, VR; Santella, JB; Sistla, R; Wu, H Heteroaryl substituted pyridyl compounds useful as kinase modulators US Patent US10023562 Publication Date 7/17/2018
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Human
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM283824
Synonyms:
US10023562, Example 18 | US10544133, Example 18 | US9657009, 18
Type:
Small organic molecule
Emp. Form.:
C23H28FN7O2
Mol. Mass.:
453.5125
SMILES:
CNC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnc(Nc2ncc(cc2F)C#N)cc1NC(C)C |r,wU:4.3,wD:7.10,(-10.67,1.93,;-9.34,1.15,;-8,1.93,;-8,3.47,;-6.67,1.15,;-5.33,1.93,;-4,1.15,;-4,-.38,;-5.33,-1.15,;-6.67,-.38,;-2.67,-1.15,;-1.33,-.38,;-1.33,1.15,;,-1.15,;,-2.69,;1.33,-3.47,;2.67,-2.69,;4,-3.47,;5.33,-2.69,;6.67,-3.47,;8,-2.69,;8,-1.15,;6.67,-.38,;5.33,-1.15,;4,-.38,;9.34,-.38,;10.67,-1.15,;2.67,-1.15,;1.33,-.38,;1.33,1.15,;2.67,1.93,;2.67,3.47,;4,1.16,)|