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Target
Phospholipase D
Ligand
BDBM123759
Substrate
n/a
Meas. Tech.
PLD In Vitro Kinetic Assay
Temperature
310.15±0 K
IC50
1750±n/a nM
Citation
 Kulkarni, A; Quang, P; Curry, V; Keyes, R; Zhou, W; Cho, H; Baffoe, J; Torok, B; Stieglitz, K 1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D. Chem Biol Drug Des 84:270-81 (2014) [PubMed]  Article 
Target
Name:
Phospholipase D
Synonyms:
Phospholipase D (PLD_sp)
Type:
Protein
Mol. Mass.:
54006.04
Organism:
Streptomyces sp. PMF
Description:
P84147
Residue:
506
Sequence:
ADSATPHLDAVEQTLRQVSPGLEGDVWERTSGNKLDGSAADPSDWLLQTPGCWGDDKCADRVGTKRLLAKMTENIGNATRTVDISTLAPFPNGAFQDAIVAGLKESAAKGNKLKVRILVGAAPVYHMNVIPSKYRDELTAKLGKAAENITLNVASMTTSKTAFSWNHSKILVVDGQSALTGGINSWKDDYLDTTHPVSDVDLALTGPAAGSAGRYLDTLWTWTCQNKSNIASVWFAASGNAGCMPTMHKDTNPKASPATGNVPVIAVGGLGVGIKDVDPKSTFRPDLPTASDTKCVVGLHDNTNADRDYDTVNPEESALRALVASAKGHIEISQQDLNATCPPLPRYDIRLYDALAAKMAAGVKVRIVVSDPANRGAVGSGGYSQIKSLSEISDTLRNRLANITGGQQAAKTAMCSNLQLATFRSSPNGKWADGHPYAQHHKLVSVDSSTFYIGSKNLYPSWLQDFGYIVESPEAAKQLDAKLLDPQWKYSQETATVDYARGICNA
  
Inhibitor
Name:
BDBM123759
Synonyms:
3‐(naphthalen‐2‐yl)‐1H‐pyrazolo[3,4‐d]pyrimidin‐4‐ amine (18)
Type:
Small organic molecule
Emp. Form.:
C15H11N5
Mol. Mass.:
261.2813
SMILES:
Nc1ncnc2n[nH]c(-c3ccc4ccccc4c3)c12
Structure:
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