Reaction Details Report a problem with these data
Target
Endothelial lipase
Ligand
BDBM123906
Substrate
n/a
Meas. Tech.
Inhibition Assay
Temperature
310.15±n/a K
IC50
14±n/a nM
Comments
extracted
Citation
 Masuda, K; Kida, S; Yoshikawa, N; Katou, M; Kato, T; Nakajima, M; Kojima, E; Yonehara, M Oxadiazole derivative having endothelial lipase inhibitory activity US Patent  US8754113 Publication Date 6/17/2014 
Target
Name:
Endothelial lipase
Synonyms:
EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:
Protein
Mol. Mass.:
56805.62
Organism:
Human
Description:
Q9Y5X9
Residue:
500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVVVDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKNMGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGASQSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWFRKCRDGWRMKNETSPTVELP
  
Inhibitor
Name:
BDBM123906
Synonyms:
US8754113, I-3-41
Type:
Small organic molecule
Emp. Form.:
C23H18FN5O2S
Mol. Mass.:
447.485
SMILES:
Fc1ccc(Cc2ccc3nc(Cc4nnc(CC(=O)NC5(CC5)C#N)o4)sc3c2)cc1
Structure:
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