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Target
Cyclin-T1
Ligand
BDBM126407
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.03728±n/a nM
Citation
 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent  US8778951 Publication Date 7/15/2014 
Target
Name:
Cyclin-T1
Synonyms:
CCNT1 | CCNT1_HUMAN | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T
Type:
Enzyme Subunit
Mol. Mass.:
80712.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
726
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
  
Inhibitor
Name:
BDBM126407
Synonyms:
US8778951, 217
Type:
Small organic molecule
Emp. Form.:
C24H33ClN6O
Mol. Mass.:
457.011
SMILES:
CC(=O)N1CCC[C@@H](CNc2cccc(n2)-c2cc(N[C@H]3CC[C@H](N)CC3)ncc2Cl)C1 |r,wU:7.7,20.20,wD:23.24,(6.39,-2.94,;5.06,-2.17,;5.06,-.63,;3.72,-2.94,;3.72,-4.48,;2.39,-5.25,;1.06,-4.48,;1.06,-2.94,;-.28,-2.17,;-1.61,-2.94,;-2.94,-2.17,;-4.28,-2.94,;-5.61,-2.17,;-5.61,-.63,;-4.28,.14,;-2.94,-.63,;-4.28,1.68,;-2.94,2.45,;-2.94,3.99,;-1.61,4.76,;-.28,3.99,;1.06,4.76,;2.39,3.99,;2.39,2.45,;3.72,1.68,;1.06,1.68,;-.28,2.45,;-4.28,4.76,;-5.61,3.99,;-5.61,2.45,;-6.95,1.68,;2.39,-2.17,)|
Structure:
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