Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50123963
Substrate
n/a
Meas. Tech.
Inhibition of Histone Deacetylase Enzymatic Assay
Temperature
310.15±n/a K
IC50
3000±n/a nM
Comments
extracted
Citation
 Déziel, R; Ajamian, A Inhibitors of histone deacetylase and prodrugs thereof US Patent  US8796330 Publication Date 8/5/2014 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50123963
Synonyms:
3-[4-(Biphenyl-4-sulfonylamino)-phenyl]-propynoic acid (2-amino-phenyl)-amide | CHEMBL165693 | US8796330, 129
Type:
Small organic molecule
Emp. Form.:
C27H21N3O3S
Mol. Mass.:
467.539
SMILES:
Nc1ccccc1NC(=O)C#Cc1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)cc1
Structure:
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