Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM141814
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
13.4±n/a nM
Citation
 Rodriguez Sarmiento, RM; Wichmann, J Benzofurane-piperidine compounds US Patent  US8921397 Publication Date 12/30/2014 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM141814
Synonyms:
US8921397, 56
Type:
Small organic molecule
Emp. Form.:
C22H30N2O2
Mol. Mass.:
354.4858
SMILES:
O=CN[C@H]1CC[C@H](CCN2CCC(CC2)c2coc3ccccc23)CC1 |r,wU:6.6,wD:3.2,(7.15,2.67,;7.92,1.33,;7.15,,;5.61,,;4.84,1.33,;3.3,1.33,;2.53,,;.99,,;.22,-1.33,;-1.32,-1.33,;-2.09,,;-3.63,,;-4.4,-1.33,;-3.63,-2.67,;-2.09,-2.67,;-5.94,-1.33,;-6.85,-2.58,;-8.31,-2.1,;-8.31,-.56,;-9.46,.47,;-9.14,1.97,;-7.67,2.45,;-6.53,1.42,;-6.85,-.09,;3.3,-1.33,;4.84,-1.33,)|
Structure:
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