Reaction Details Report a problem with these data
Target
Caspase-10
Ligand
BDBM160849
Substrate
n/a
Meas. Tech.
Fluorometric Enzymatic Assay
IC50
2000±n/a nM
Citation
 Ahlfors, J; Mekouar, K Selective caspase inhibitors and uses thereof US Patent  US9045524 Publication Date 6/2/2015 
Target
Name:
Caspase-10
Synonyms:
CASP10 | CASPA_HUMAN | MCH4
Type:
Enzyme
Mol. Mass.:
58956.47
Organism:
Homo sapiens (Human)
Description:
Q92851
Residue:
521
Sequence:
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS
  
Inhibitor
Name:
BDBM160849
Synonyms:
US9045524, 123
Type:
Small organic molecule
Emp. Form.:
C31H37ClN4O11S
Mol. Mass.:
709.164
SMILES:
CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)OCc1ccccc1)c1ccccc1)C(=O)N[C@@H](CC(O)=O)\C=C(/Cl)S(C)(=O)=O |r|
Structure:
Search PDB for entries with ligand similarity: