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Target
von Hippel-Lindau disease tumor suppressor
Ligand
BDBM171823
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.5±n/a
IC50
760±0 nM
Comments
extracted
Citation
 Flamme, I; Ergüden, J; Oehme, F; Thede, K; Karig, G; Kuhl, A; Wild, H; Schuhmacher, J; Kolkhof, P; Bärfacker, L; Hütter, J 4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases US Patent  US9085572 Publication Date 7/21/2015 
Target
Name:
von Hippel-Lindau disease tumor suppressor
Synonyms:
Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:
Protein
Mol. Mass.:
24136.87
Organism:
Homo sapiens (Human)
Description:
P40337
Residue:
213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
  
Inhibitor
Name:
BDBM171823
Synonyms:
US9085572, 26
Type:
n/a
Emp. Form.:
C14H12N4O
Mol. Mass.:
252.2713
SMILES:
Cc1ncccc1-c1c[nH]n(-c2ccccn2)c1=O
Structure:
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