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Target
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2
Ligand
BDBM172197
Substrate
n/a
Meas. Tech.
HTS Assay
Temperature
298.15±n/a K
IC50
3900±n/a nM
Comments
extracted
Citation
 Wagner, FF; Pan, JQ; Dandapani, S; Germain, A; Holson, E; Munoz, B; Nag, PP; Weiwer, M; Lewis, MC; Haggarty, SJ; Bishop, JA; Stegmaier, K; Banerji, V Kinase inhibitors and methods of use thereof US Patent  US9096594 Publication Date 8/4/2015 
Target
Name:
Cyclin-A2 [177-432]/Cyclin-dependent kinase 2
Synonyms:
CDK2/Cyclin A2 | Cyclin-Dependent Kinase 2 (CDK2)
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Component 2
Name:
Cyclin-A2 [177-432]
Synonyms:
CCN1 | CCNA | CCNA2 | CCNA2_HUMAN | Cyclin A2 | Cyclin-A
Type:
Subunit of Enzyme Complex
Mol. Mass.:
29394.24
Organism:
Homo sapiens (Human)
Description:
P20248[177-432]
Residue:
256
Sequence:
DYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPESLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLLNPPETLNL
  
Inhibitor
Name:
BDBM172197
Synonyms:
US9090564, 11 | US9096594, 54
Type:
Small organic molecule
Emp. Form.:
C22H19ClN4O
Mol. Mass.:
390.865
SMILES:
CN(C)C(=O)c1ccc(cc1Cl)-c1ccnc(C)c1C#Cc1ccc(N)nc1
Structure:
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