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Target
Non-secretory ribonuclease
Ligand
BDBM173618
Substrate
n/a
Meas. Tech.
Ribonuclease Activity Assay
Temperature
303.15±n/a K
Ki
2.61e+4± 3.4e+3 nM
IC50
3.31e+4± 5e+2 nM
Comments
extracted
Citation
 Chatzileontiadou, DS; Parmenopoulou, V; Manta, S; Kantsadi, AL; Kylindri, P; Griniezaki, M; Kontopoulou, F; Telopoulou, A; Prokova, H; Panagopoulos, D; Boix, E; Balatsos, NA; Komiotis, D; Leonidas, DD Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Bioorg Chem 63:152-65 (2015) [PubMed]  Article 
Target
Name:
Non-secretory ribonuclease
Synonyms:
EDN | Eosinophil-derived neurotoxin (EDN) | Non-secretory ribonuclease | RNAS2_HUMAN | RNASE2 | RNAse 2 | RNS2
Type:
Protein
Mol. Mass.:
18364.09
Organism:
Human
Description:
n/a
Residue:
161
Sequence:
MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
  
Inhibitor
Name:
BDBM173618
Synonyms:
1-[(2R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione (IV)
Type:
Small organic molecule
Emp. Form.:
C10H14N2O6
Mol. Mass.:
258.228
SMILES:
Cc1cn([C@@H]2O[C@H](CO)[C@H](O)C2O)c(=O)[nH]c1=O |r|
Structure:
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