Reaction Details Report a problem with these data
Target
Insulin receptor [964-1370]
Ligand
BDBM184386
Substrate
n/a
Meas. Tech.
DELFIA Assay
pH
7.4±n/a
IC50
0.17±n/a nM
Comments
extracted
Citation
 Treu, M 5,8-dihydro-6H-pyrazolo[3,4-h]quinazolines as IGF-1R/IR inhibitors US Patent  US9150578 Publication Date 10/6/2015 
Target
Name:
Insulin receptor [964-1370]
Synonyms:
INSR | INSR_HUMAN | Insulin-like growth factor 1 receptor (aa 964-1370)
Type:
n/a
Mol. Mass.:
46101.87
Organism:
Homo sapiens (Human)
Description:
P06213[964-1370]
Residue:
407
Sequence:
FVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKN
  
Inhibitor
Name:
BDBM184386
Synonyms:
US9150578, I-034
Type:
Small organic molecule
Emp. Form.:
C31H37N11
Mol. Mass.:
563.6992
SMILES:
CN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(Cc6cccc(c6)-c6cnn(C)c6)c5-c4n3)n2)CC1
Structure:
Search PDB for entries with ligand similarity: