Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM203296
Substrate
n/a
Meas. Tech.
IRAK4 Inhibition Assay
pH
7.2±n/a
Temperature
298.15±n/a K
IC50
875±n/a nM
Comments
extracted
Citation
 Paidi, VR; Kumar, SR; Banerjee, A; Sistla, R; Nair, SK; Pitts, WJ; Hynes, J Heterocyclic-substituted pyridyl compounds useful as kinase inhibitors US Patent  US9242975 Publication Date 1/26/2016 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM203296
Synonyms:
US10227340, Example 106 | US9242975, 106
Type:
Small organic molecule
Emp. Form.:
C24H28N6O3S
Mol. Mass.:
480.583
SMILES:
CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1-c1nc(NC(=O)OC(C)(C)C)c(C)o1
Structure:
Search PDB for entries with ligand similarity: