Reaction Details
Report a problem with these data
![](/images/Email.png)
Target
Isoform D of Beta-secretase 1 (BACE-I-432)
Ligand
BDBM223395
Substrate
n/a
Meas. Tech.
BACE1 Cell-Free Assay
pH
4.5±n/a
Temperature
310.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
![](/images/small/blackdot.gif)
More Info.:
Target
Name:
Isoform D of Beta-secretase 1 (BACE-I-432)
Synonyms:
BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (BACE-I-432) | Beta-secretase 1 (BACE1) | KIAA1149
Type:
Protein
Mol. Mass.:
48152.67
Organism:
Homo sapiens (Human)
Description:
P56817-4
Residue:
432
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK
Inhibitor
Name:
BDBM223395
Synonyms:
US9315520, 1 | US9315520, Comparator 1 | US9315520, Example 1 | US9315520, Example 2 | US9605007, Example 1
Type:
Small organic molecule
Emp. Form.:
C18H19F2N5O3S2
Mol. Mass.:
455.502
SMILES:
C[C@H]1C[C@H]2CSC(N)=N[C@]2(CO1)c1nc(NC(=O)c2ccc(OC(F)F)cn2)cs1 |r,c:7|