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Target
Bromodomain-containing protein 4 [342-460]
Ligand
BDBM343489
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
IC50
<1000±n/a nM
Citation
 Rodgers, JD; Shepard, S; Wang, H; Shao, L Tricyclic heterocycles as bet protein inhibitors US Patent  US10442803 Publication Date 10/15/2019 
Target
Name:
Bromodomain-containing protein 4 [342-460]
Synonyms:
BRD4 | BRD4-BD2 (aa 342-460) | BRD4_HUMAN | Bromodomain containing 4 (aa 342-460) | Bromodomain-containing protein 4 (BRD4)(BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13783.81
Organism:
Human
Description:
a.a. 342-460 (BRD4-BD2)
Residue:
119
Sequence:
PAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDE
  
Inhibitor
Name:
BDBM343489
Synonyms:
US10442803, Example 88 | US11091484, Example 88 | US9777003, Example 88
Type:
Small organic molecule
Emp. Form.:
C23H21N7
Mol. Mass.:
395.4597
SMILES:
CC(Cn1ccc(n1)-c1cc2c(ccc3nnc(C)n23)n1Cc1ccccc1)C#N |w:1.0|
Structure:
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