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Target
Histone deacetylase 2
Ligand
BDBM425892
Substrate
n/a
Meas. Tech.
In vitro enzymatic HDACs assays
IC50
20000±n/a nM
Citation
 Schultz, J; Vågberg, J; Olsson, E; Färnegårdh, K; Jönsson, M; Hammer, K; Krüger, L Benzimidazole derivates useful as inhibitors of mammalian histone deacetylase activity US Patent  US10512634 Publication Date 12/24/2019 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM425892
Synonyms:
N-hydroxy-2-(4-methoxy- 3,5-dimethylphenyl)-1- methyl-1H-benzimidazole- 5-carboxamide | US10512634, Example 228
Type:
Small organic molecule
Emp. Form.:
C18H19N3O3
Mol. Mass.:
325.3618
SMILES:
COc1c(C)cc(cc1C)-c1nc2cc(ccc2n1C)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: