Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM426456
Substrate
n/a
Meas. Tech.
FLIPR Assay
IC50
20.6±n/a nM
Citation
 Kuduk, SD; Liverton, N; Beshore, DC; Meng, N; Luo, Y Fused heteroaryl derivatives as orexin receptor antagonists US Patent  US10526336 Publication Date 1/7/2020 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM426456
Synonyms:
((2R,5R)-2-methyl-5-(pyrazolo[1,5- alpha]pyrazin-4-yloxy)piperidin-1-yl) (2-(pyrimidin-2-yl)thiophen-3-yl) methanone | US10526336, Example 75
Type:
Small organic molecule
Emp. Form.:
C21H20N6O2S
Mol. Mass.:
420.487
SMILES:
C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)Oc1nccn2ccnc12 |r|
Structure:
Search PDB for entries with ligand similarity: