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Target
RAC-alpha serine/threonine-protein kinase [E17K]
Ligand
BDBM431875
Substrate
n/a
Meas. Tech.
Biochemical Assays
IC50
1951±162 nM
Citation
 Rauh, D; Gontla, R; Weisner, J Kinase inhibitors and their use in cancer therapy US Patent  US10550114 Publication Date 2/4/2020 
Target
Name:
RAC-alpha serine/threonine-protein kinase [E17K]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | RAC-alpha serine/threonine-protein kinase AKT1 (E17K)
Type:
Enzyme
Mol. Mass.:
55682.32
Organism:
Human
Description:
P31749 (E17K)
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGKYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM431875
Synonyms:
US10550114, Compound 30
Type:
Small organic molecule
Emp. Form.:
C36H33ClN6O3
Mol. Mass.:
633.139
SMILES:
Clc1ccc(NC(=O)NC2CCN(Cc3ccc(cc3)-c3nc4cc[nH]c(=O)c4cc3-c3ccccc3)CC2)cc1NC(=O)C=C
Structure:
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