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Target
RAC-alpha serine/threonine-protein kinase [E17K]
Ligand
BDBM431877
Substrate
n/a
Meas. Tech.
Biochemical Assays
IC50
525±43 nM
Citation
 Rauh, D; Gontla, R; Weisner, J Kinase inhibitors and their use in cancer therapy US Patent  US10550114 Publication Date 2/4/2020 
Target
Name:
RAC-alpha serine/threonine-protein kinase [E17K]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | RAC-alpha serine/threonine-protein kinase AKT1 (E17K)
Type:
Enzyme
Mol. Mass.:
55682.32
Organism:
Homo sapiens (Human)
Description:
P31749 (E17K)
Residue:
480
Sequence:
MSDVAIVKEGWLHKRGKYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
  
Inhibitor
Name:
BDBM431877
Synonyms:
US10550114, Compound 32
Type:
Small organic molecule
Emp. Form.:
C36H33N5O3
Mol. Mass.:
583.6789
SMILES:
C=CC(=O)Nc1cccc(c1)C(=O)NC1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1
Structure:
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