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Target
Prostacyclin receptor
Ligand
BDBM444835
Substrate
n/a
Meas. Tech.
Homogeneous Time-Resolved Fluorescence (HTRF) Assay for Direct cAMP Measurement
EC50
19.1±n/a nM
Citation
 Tran, T; Chen, W; Kramer, BA; Sadeque, AJ; Shifrina, A; Shin, Y; Vallar, P; Zou, N Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto US Patent  US10668033 Publication Date 6/2/2020 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM444835
Synonyms:
2-(((1r,4r)-4-(((3- fluorophenyl)(5-methylthiophen- 2-yl)carbamoyloxy)methyl) cyclohexyl)methoxy)acetic acid | US10668033, Compound 71
Type:
Small organic molecule
Emp. Form.:
C22H26FNO5S
Mol. Mass.:
435.509
SMILES:
Cc1ccc(s1)N(C(=O)OC[C@H]1CC[C@H](COCC(O)=O)CC1)c1cccc(F)c1 |r,wU:11.11,wD:14.15,(-9.96,2.46,;-8.42,2.46,;-7.51,3.7,;-6.05,3.23,;-6.05,1.69,;-7.51,1.21,;-4.71,.92,;-3.38,1.69,;-3.38,3.23,;-2.05,.92,;-.71,1.69,;.62,.92,;1.95,1.69,;3.29,.92,;3.29,-.62,;4.62,-1.39,;5.96,-.62,;7.29,-1.39,;8.62,-.62,;9.96,-1.39,;8.62,.92,;1.95,-1.39,;.62,-.62,;-4.71,-.62,;-6.05,-1.39,;-6.05,-2.93,;-4.71,-3.7,;-3.38,-2.93,;-2.05,-3.7,;-3.38,-1.39,)|
Structure:
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