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Target
Proteasome subunit beta type-5
Ligand
BDBM446681
Substrate
n/a
Meas. Tech.
Determination of Beta5 Activity
IC50
2750±n/a nM
Citation
 Klein, M; Schadt, O; Haselmayer, P; Krier, M Boronic acid derivatives US Patent  US10669289 Publication Date 6/2/2020 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM446681
Synonyms:
US10669289, Compound 88
Type:
Small organic molecule
Emp. Form.:
C15H21BN2O4
Mol. Mass.:
304.149
SMILES:
Cc1ccc(CC(NC(=O)CNC(=O)C=C)B(O)O)cc1C
Structure:
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