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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM447464
Substrate
n/a
Meas. Tech.
Inhibition of Test Compounds NAAA Assay
IC50
55±n/a nM
Citation
 Malamas, MS; Makriyannis, A; Farah, SI; Zvonok, AM; Alapafuja, SO N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and use thereof US Patent  US10689357 Publication Date 6/23/2020 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | ASAHL | Acid ceramidase-like protein | N-acylethanolamine-hydrolyzing acid amidase | N-acylsphingosine amidohydrolase-like | N-acylsphingosine-amidohydrolase | NAAA | NAAA_HUMAN | PLT
Type:
Enzyme
Mol. Mass.:
40073.12
Organism:
Homo sapiens (Human)
Description:
Q02083
Residue:
359
Sequence:
MRTADREARPGLPSLLLLLLAGAGLSAASPPAAPRFNVSLDSVPELRWLPVLRHYDLDLVRAAMAQVIGDRVPKWVHVLIGKVVLELERFLPQPFTGEIRGMCDFMNLSLADCLLVNLAYESSVFCTSIVAQDSRGHIYHGRNLDYPFGNVLRKLTVDVQFLKNGQIAFTGTTFIGYVGLWTGQSPHKFTVSGDERDKGWWWENAIAALFRRHIPVSWLIRATLSESENFEAAVGKLAKTPLIADVYYIVGGTSPREGVVITRNRDGPADIWPLDPLNGAWFRVETNYDHWKPAPKEDDRRTSAIKALNATGQANLSLEALFQILSVVPVYNNFTIYTTVMSAGSPDKYMTRIRNPSRK
  
Inhibitor
Name:
BDBM447464
Synonyms:
US10689357, Example 3
Type:
Small organic molecule
Emp. Form.:
C19H17NO3S
Mol. Mass.:
339.408
SMILES:
COc1cccc(c1)-c1ccc(cc1)C(=O)O[C@H]1C[C@H](C1)N=C=S |r,wU:17.18,19.23,(-5.61,-5.55,;-6.94,-4.78,;-6.94,-3.24,;-8.28,-2.47,;-8.28,-.93,;-6.94,-.16,;-5.61,-.93,;-5.61,-2.47,;-4.28,-.16,;-4.28,1.38,;-2.94,2.15,;-1.61,1.38,;-1.61,-.16,;-2.94,-.93,;-.28,2.15,;-.28,3.69,;1.06,1.38,;2.39,2.15,;2.79,3.64,;4.28,3.24,;3.88,1.75,;5.61,4.01,;6.94,4.78,;8.28,5.55,)|
Structure:
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