Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK2 [828-1132]
Ligand
BDBM448619
Substrate
n/a
Meas. Tech.
In vitro JAK Kinase Assay
IC50
30.0±n/a nM
Citation
 Huang, T; Xue, C Piperidin-4-yl azetidine derivatives as JAK1 inhibitors US Patent  US10695337 Publication Date 6/30/2020 
Target
Name:
Tyrosine-protein kinase JAK2 [828-1132]
Synonyms:
JAK2 | JAK2 (aa 828-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2
Type:
n/a
Mol. Mass.:
35579.28
Organism:
Human
Description:
O60674[828-1132]
Residue:
305
Sequence:
GALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM448619
Synonyms:
4-{3-(cyanomethyl)-3-[4-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-1H-pyrazol-1- yl]azetidin-1-yl}-N-(2-methylphenyl) piperidine-1-carboxamide | US10695337, Example 185
Type:
Small organic molecule
Emp. Form.:
C27H29N9O
Mol. Mass.:
495.5789
SMILES:
Cc1cc(ccc1NC(=O)N1CCCCC1)N1CC(CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12
Structure:
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