Target
Nuclear receptor ROR-gamma [262-507]
Ligand
BDBM382681
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
27.0±n/a nM
Citation
 Duan, JDhar, TGMarcoux, DCherney, RJ Tricyclic sulfones as RORγ modulators US Patent  US10711020 Publication Date 7/14/2020 
Target
Name:
Nuclear receptor ROR-gamma [262-507]
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (aa 262-507) | ROR-gamma (A262-S507) | RORC | RORG | RORG_HUMAN | RZRG
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28605.37
Organism:
Homo sapiens (Human)
Description:
aa 262-507
Residue:
246
Sequence:
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
  
Inhibitor
Name:
BDBM382681
Synonyms:
US10273259, Example 390 | US10273259, Example 391 | US10711020, Example 391
Type:
Small organic molecule
Emp. Form.:
C28H27ClF7NO5S2
Mol. Mass.:
690.09
SMILES:
CC1CC(CCS1(=O)=O)C(=O)N1CCC2(C1CCc1cc(ccc21)C(F)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1
Structure:
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