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Target
Mitogen-activated protein kinase kinase kinase kinase 1
Ligand
BDBM455829
Substrate
n/a
Meas. Tech.
Kinase Binding Assay
Ki
<100±n/a nM
Citation
 Vechorkin, O; Atasoylu, O; Ye, HF; Liu, K; Zhang, K; Yao, W Cyanoindazole compounds and uses thereof US Patent  US10722495 Publication Date 7/28/2020 
Target
Name:
Mitogen-activated protein kinase kinase kinase kinase 1
Synonyms:
HPK1 | M4K1_HUMAN | MAP4K1
Type:
PROTEIN
Mol. Mass.:
91316.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586597
Residue:
833
Sequence:
MDVVDPDIFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTKDQHLLLGAEEGIFILNRNDQEATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERKETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCVAEGASSGGPFLCGALETSVVLLQWYQPMNKFLLVRQVLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRFGALSCWLGEMSTEHRGPVQVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPEIPMTEAVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLECSGTISPHCNLLLPGSSNSPASASRVAGITGL
  
Inhibitor
Name:
BDBM455829
Synonyms:
US10722495, Example 37
Type:
Small organic molecule
Emp. Form.:
C20H16FN5S
Mol. Mass.:
377.438
SMILES:
CNCc1cc(C)c(c(F)c1)-c1cc2c(n[nH]c2cc1C#N)-c1cnsc1 |(1.45,5.07,;.12,5.84,;-1.21,5.07,;-1.21,3.53,;.12,2.76,;.12,1.22,;1.45,.45,;-1.21,.45,;-2.55,1.22,;-3.88,.45,;-2.55,2.76,;-1.21,-1.09,;.12,-1.86,;.12,-3.4,;1.27,-4.43,;.64,-5.84,;-.89,-5.68,;-1.21,-4.17,;-2.55,-3.4,;-2.55,-1.86,;-3.88,-1.09,;-5.21,-.32,;2.75,-4.03,;3.45,-2.66,;4.97,-2.9,;5.21,-4.42,;3.84,-5.12,)|
Structure:
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