Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM464472
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
190±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Jakob, F; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W 3-((hetero-)aryl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10793528 Publication Date 10/6/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM464472
Synonyms:
US10793528, Example SC_5042
Type:
Small organic molecule
Emp. Form.:
C28H43N5O4
Mol. Mass.:
513.6721
SMILES:
COCCCN1C(=O)N(CCC(=O)N2CCC[C@@H]2C(N)=O)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1 |r,wU:22.23,25.30,17.18,(-.02,-5.54,;-.02,-4,;1.01,-2.86,;.53,-1.39,;1.56,-.25,;1.09,1.22,;-.38,1.69,;-1.62,.79,;-.38,3.23,;-1.71,4,;-3.05,3.23,;-4.38,4,;-4.38,5.54,;-5.71,3.23,;-7.12,3.86,;-8.15,2.71,;-7.38,1.38,;-5.87,1.7,;-4.73,.67,;-5.05,-.84,;-3.27,1.15,;1.09,3.71,;1.99,2.46,;2.76,1.13,;4.3,1.13,;5.07,2.46,;4.3,3.8,;2.76,3.8,;5.84,3.8,;7.38,3.8,;5.07,5.13,;5.84,1.13,;5.07,-.21,;5.84,-1.54,;7.38,-1.54,;8.15,-.21,;7.38,1.13,)|
Structure:
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