Reaction Details Report a problem with these data
Target
Protein M2-1
Ligand
BDBM301499
Substrate
n/a
Meas. Tech.
Antiviral Activity
EC50
1.58±n/a nM
Citation
 Tahari, A; Vendeville, SM; Jonckers, TH; Raboisson, PJ; Demin, SD; Hu, L Piperidine substituted tricyclic pyrazolo[1,5-a]pyrimidine derivatives with inhibitory activity on the replication of the respiratory syncytial virus (RSV) US Patent  US10131673 Publication Date 11/20/2018 
Target
Name:
Protein M2-1
Synonyms:
Envelope-associated 22 kDa protein | M2-1 | M21_HRSVA | Matrix M2-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
22163.59
Organism:
Human respiratory syncytial virus A (strain A2)
Description:
P04545
Residue:
194
Sequence:
MSRRNPCKFEIRGHCLNGKRCHFSHNYFEWPPHALLVRQNFMLNRILKSMDKSIDTLSEISGAAELDRTEEYALGVVGVLESYIGSINNITKQSACVAMSKLLTELNSDDIKKLRDNEELNSPKIRVYNTVISYIESNRKNNKQTIHLLKRLPADVLKKTIKNTLDIHKSITINNPKESTVSDTNDHAKNNDTT
  
Inhibitor
Name:
BDBM301499
Synonyms:
N-(2-(2-(9-(dimethylamino)-5-methyl-5,6,7,8-tetrahydropyrazolo-[1,5-a]pyrido[2,3-d]pyrimidin-2-yl)piperidine-1-carbonyl)-4-methylphenyl)-methane-sulfonamide | US10131673, Compound P26
Type:
Small organic molecule
Emp. Form.:
C26H35N7O3S
Mol. Mass.:
525.666
SMILES:
CN(C)c1c2CCCN(C)c2nc2cc(nn12)C1CCCCN1C(=O)c1cc(C)ccc1NS(C)(=O)=O
Structure:
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