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Target
Receptor-type tyrosine-protein kinase FLT3
Ligand
BDBM239041
Substrate
n/a
Meas. Tech.
FLT3 Kinase Assay
IC50
52.0±n/a nM
Citation
 Lombardi Borgia, A; Ciomei, M; Donati, D; Nesi, M Substituted indazole derivatives active as kinase inhibitiors US Patent  US9597317 Publication Date 3/21/2017 
Target
Name:
Receptor-type tyrosine-protein kinase FLT3
Synonyms:
CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1
Type:
Enzyme
Mol. Mass.:
112888.62
Organism:
Homo sapiens (Human)
Description:
P36888
Residue:
993
Sequence:
MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESPEDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDLQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRECTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYEIDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
  
Inhibitor
Name:
BDBM239041
Synonyms:
US10028934, Compound 41 | US10478423, Cpd. 41 | US9408850, 41 | US9597317, 41
Type:
Small organic molecule
Emp. Form.:
C30H35N5O4
Mol. Mass.:
529.63
SMILES:
CN(C1CC[N+](C)([O-])CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12 |(3.97,5.33,;5.06,4.24,;6.55,4.64,;7.64,3.55,;9.13,3.95,;9.53,5.43,;11.01,5.03,;9.92,6.92,;8.44,6.52,;6.95,6.12,;4.66,2.75,;5.75,1.66,;5.36,.17,;3.87,-.22,;2.78,.86,;3.18,2.35,;3.47,-1.71,;1.98,-2.11,;4.56,-2.8,;3.79,-4.13,;4.69,-5.38,;3.79,-6.63,;2.32,-6.15,;.99,-6.92,;-.34,-6.15,;-1.68,-6.92,;-3.01,-6.15,;-4.34,-6.92,;-5.68,-6.15,;-7.01,-6.92,;-8.35,-6.15,;-8.35,-4.61,;-9.68,-3.84,;-11.01,-4.61,;-11.01,-6.15,;-9.68,-6.92,;-.34,-4.61,;.99,-3.84,;2.32,-4.61,)|
Structure:
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