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Target
CREB-binding protein [1081-1197]
Ligand
BDBM511319
Substrate
n/a
Meas. Tech.
CBP AlphaScreen Assay
IC50
18.0±n/a nM
Citation
 Le, K; Soth, MJ; Jones, P; Cross, JB; Carroll, CL; McAfoos, TJ; Mandal, PK Imidazopiperazine inhibitors of transcription activating proteins US Patent  US11058688 Publication Date 7/13/2021 
Target
Name:
CREB-binding protein [1081-1197]
Synonyms:
CBP | CBP_HUMAN | CREB-binding protein (CBP)(1081-1197) | CREBBP
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13987.94
Organism:
Homo sapiens (Human)
Description:
Q92793[1081-1197]
Residue:
117
Sequence:
RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG
  
Inhibitor
Name:
BDBM511319
Synonyms:
3-(3,3-Difluorocyclobutyl)-N-methyl-1-(2-(1-methyl-1H-pyrazol-4-yl)-3-(trifluoromethyl)quinolin-5-yl)-5,6-dihydroimidazo[1,5-a]pyrazine-7(8H)-carboxamide | US11058688, Example 20
Type:
Small organic molecule
Emp. Form.:
C26H24F5N7O
Mol. Mass.:
545.5071
SMILES:
CNC(=O)N1CCn2c(C1)c(nc2C1CC(F)(F)C1)-c1cccc2nc(-c3cnn(C)c3)c(cc12)C(F)(F)F
Structure:
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