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Target
CREB-binding protein [1081-1197]
Ligand
BDBM511390
Substrate
n/a
Meas. Tech.
CBP AlphaScreen Assay
IC50
1.000±n/a nM
Citation
 Le, K; Soth, MJ; Jones, P; Cross, JB; Carroll, CL; McAfoos, TJ; Mandal, PK Imidazopiperazine inhibitors of transcription activating proteins US Patent  US11058688 Publication Date 7/13/2021 
Target
Name:
CREB-binding protein [1081-1197]
Synonyms:
CBP | CBP_HUMAN | CREB-binding protein (CBP)(1081-1197) | CREBBP
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13987.94
Organism:
Homo sapiens (Human)
Description:
Q92793[1081-1197]
Residue:
117
Sequence:
RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG
  
Inhibitor
Name:
BDBM511390
Synonyms:
1-(7-fluoro-3-(2- methylthiazol-5- yl)isoquinolin-8-yl)-N- methyl-3-(tetrahydro-2H- pyran-4-yl)-5,6- dihydroimidazo[1,5- a]pyrazine-7(8H)- carboxamide | US11058688, Example 89 | US11058688, Example 95
Type:
Small organic molecule
Emp. Form.:
C26H27FN6O2S
Mol. Mass.:
506.595
SMILES:
CNC(=O)N1CCn2c(C1)c(nc2C1CCOCC1)-c1c(F)ccc2cc(ncc12)-c1cnc(C)s1 |(-5.55,.26,;-4.22,1.03,;-2.89,.26,;-2.89,-1.28,;-1.55,1.03,;-1.55,2.57,;-.22,3.34,;1.11,2.57,;1.11,1.03,;-.22,.26,;2.58,.55,;3.48,1.8,;2.58,3.05,;2.98,4.53,;4.47,4.93,;4.86,6.42,;3.77,7.51,;2.29,7.11,;1.89,5.62,;2.98,-.93,;4.47,-1.33,;5.55,-.24,;4.86,-2.82,;3.77,-3.91,;2.29,-3.51,;1.2,-4.6,;-.29,-4.2,;-.69,-2.71,;.4,-1.62,;1.89,-2.02,;-1.38,-5.29,;-1.14,-6.81,;-2.51,-7.51,;-3.6,-6.42,;-5.09,-6.82,;-2.9,-5.05,)|
Structure:
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