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Target
CREB-binding protein [1081-1197]
Ligand
BDBM511386
Substrate
n/a
Meas. Tech.
CBP AlphaScreen Assay
IC50
2.00±n/a nM
Citation
 Le, K; Soth, MJ; Jones, P; Cross, JB; Carroll, CL; McAfoos, TJ; Mandal, PK Imidazopiperazine inhibitors of transcription activating proteins US Patent  US11058688 Publication Date 7/13/2021 
Target
Name:
CREB-binding protein [1081-1197]
Synonyms:
CBP | CBP_HUMAN | CREB-binding protein (CBP)(1081-1197) | CREBBP
Type:
Enzyme Catalytic Domain
Mol. Mass.:
13987.94
Organism:
Homo sapiens (Human)
Description:
Q92793[1081-1197]
Residue:
117
Sequence:
RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG
  
Inhibitor
Name:
BDBM511386
Synonyms:
3-cyclopropyl-N-methyl- 1-(3-(1-methyl-1H- pyrazol-3-yl)isoquinolin- 8-yl)-5,6- dihydroimidazo[1,5- a]pyrazine-7(8H)- carboxamide | US11058688, Example 124 | US11058688, Example 87
Type:
Small organic molecule
Emp. Form.:
C24H25N7O
Mol. Mass.:
427.5016
SMILES:
CNC(=O)N1CCn2c(C1)c(nc2C1CC1)-c1cccc2cc(ncc12)-c1cnn(C)c1
Structure:
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