Reaction Details Report a problem with these data
Target
Ataxin-1
Ligand
BDBM511558
Substrate
n/a
Meas. Tech.
Human ATX Enzyme Inhibition Assay
IC50
1.000±n/a nM
Citation
Mattei, P; Hert, J; Hunziker, D; Rudolph, M; Schmitz, P; Di Giorgio, P; Gomme, J Heterocyclic compounds useful as dual ATX/CA inhibitors US Patent US11059794 Publication Date 7/13/2021
More Info.:
Target
Name:
Ataxin-1
Synonyms:
ATX1 | ATX1_HUMAN | ATXN1 | SCA1
Type:
Protein
Mol. Mass.:
86941.25
Organism:
Homo sapiens (Human)
Description:
P54253
Residue:
815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
Inhibitor
Name:
BDBM511558
Synonyms:
US11059794, Example 6.18 | tert-butyl 4-[2-(2-fluoro-4- sulfamoylphenyl)sulfonylethyl]- piperidine-1-carboxylate (intermediate 16)/6-(2,2,2- trifluoroethoxy)-5- (trifluoromethyl)pyridine-3- carboxylic acid (CAS-RN 1588507- 32-7)
Type:
Small organic molecule
Emp. Form.:
C22H22F7N3O6S2
Mol. Mass.:
621.545
SMILES:
NS(=O)(=O)c1ccc(c(F)c1)S(=O)(=O)CCC1CCN(CC1)C(=O)c1cnc(OCC(F)(F)F)c(c1)C(F)(F)F