Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM511565
Substrate
n/a
Meas. Tech.
Human Carbonic Anhydrase-II Inhibition Assay
IC50
6.20±n/a nM
Citation
Mattei, P; Hert, J; Hunziker, D; Rudolph, M; Schmitz, P; Di Giorgio, P; Gomme, J Heterocyclic compounds useful as dual ATX/CA inhibitors US Patent US11059794 Publication Date 7/13/2021
More Info.:
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Inhibitor
Name:
BDBM511565
Synonyms:
US11059794, Example 6.25 | tert-butyl 3-(2-fluoro-4- sulfamoylphenyl)sulfinylazetidine- 1-carboxylate (intermediate 10.3)/ 2-cyclopropyl-6-(oxan-4- ylmethoxy)pyridine-4-carboxylic acid (CAS-RN 1810776-23-8)
Type:
Small organic molecule
Emp. Form.:
C24H28FN3O6S2
Mol. Mass.:
537.624
SMILES:
NS(=O)(=O)c1ccc(c(F)c1)S(=O)C1CN(C1)C(=O)c1cc(OCC2CCOCC2)nc(c1)C1CC1