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Target
Ataxin-1
Ligand
BDBM511581
Substrate
n/a
Meas. Tech.
Human ATX Enzyme Inhibition Assay
IC50
1.000±n/a nM
Citation
 Mattei, P; Hert, J; Hunziker, D; Rudolph, M; Schmitz, P; Di Giorgio, P; Gomme, J Heterocyclic compounds useful as dual ATX/CA inhibitors US Patent  US11059794 Publication Date 7/13/2021 
Target
Name:
Ataxin-1
Synonyms:
ATX1 | ATX1_HUMAN | ATXN1 | SCA1
Type:
Protein
Mol. Mass.:
86941.25
Organism:
Homo sapiens (Human)
Description:
P54253
Residue:
815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
  
Inhibitor
Name:
BDBM511581
Synonyms:
US11059794, Example 6.41 | tert-butyl 4-(2-fluoro-4- sulfamoylphenyl)sulfonylpiperidine- 1-carboxylate (intermediate 11)/3- [4-(difluoromethoxy)-2-[(5- methyltetrazol-2- yl)methyl]phenyl]propanoic acid (intermediate 13.2)
Type:
Small organic molecule
Emp. Form.:
C24H27F3N6O6S2
Mol. Mass.:
616.633
SMILES:
Cc1nnn(Cc2cc(OC(F)F)ccc2CCC(=O)N2CCC(CC2)S(=O)(=O)c2ccc(cc2F)S(N)(=O)=O)n1
Structure:
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