Reaction Details Report a problem with these data
Target
Ketohexokinase
Ligand
BDBM511679
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1.170±n/a nM
Citation
 Dugar, S; Lanaspa-Garcia, M; Le, MT; Greenlee, WJ Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases US Patent  US11083720 Publication Date 8/10/2021 
Target
Name:
Ketohexokinase
Synonyms:
Hepatic fructokinase | KHK | KHK_HUMAN | Ketohexokinase | Ketohexokinase (KHK) | Ketohexokinase (KHK) Isoform C
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32521.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
298
Sequence:
MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCTVLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSKGDTPSSCCIINNSNGNRTIVLHDTSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHLGFQSAEEALRGLYGRVRKGAVLVCAWAEEGADALGPDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRSVQEALRFGCQVAGKKCGLQGFDGIV
  
Inhibitor
Name:
BDBM511679
Synonyms:
4-(1-phenyl-1H-indazol-6- yl)pyridin-2-amine | US11083720, Compound C-1
Type:
Small organic molecule
Emp. Form.:
C18H14N4
Mol. Mass.:
286.3306
SMILES:
Nc1cc(ccn1)-c1ccc2cnn(-c3ccccc3)c2c1
Structure:
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